Because bone marrow stromal cells bmscs contain a subset of stem cells also called mesenchymal stem cells multipotent stromal cells or skeletal stem cells that can differentiate into osteoblasts these stem cells play a vital role in the tissue engineering of new bone this article will highlight research on the use of bmscs to provide the body with a means to regenerate lost bone tissue and will discuss the challenges and possible ramifications of using such strategies in the clinic. Introductory text and sources of stem cells for skeletal tissue endothelial progenitor cell based therapy for orthopaedic regenerative medicine transplanted bone marrow stromal cells and bone tissue regeneration isolation and purification methods for mesenchymal stem cells the human nose offers a new stem cell source for bone injuries multipotential mesenchymal stromal stem cells in skeletal tissue repair adipose derived stem cells ascs and bone repair an overview in regenerative . Stem cell based bone tissue engineering offers a promising approach for regenerating critical sized bone defects or repairing nonunion bone fracture understanding and recreating a signalling environment to control the differentiation of stem cells into the bone lineage would be of great importance. Keywords stem cell therapy mesenchymal stem cells antimicrobial materials bone tissue engineer ing critical large bone defects high throughput screening systems 1 introduction artificial biomedical implants have grown more complex because of progress in manufacturing processes as well as the creation of novel materials the daily use of
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