Objectives to discuss the clinical pharmacology of currently licensed veterinary nsaids and to review gastrointestinal and renal adverse effects as well as drug drug interactions that have been reported with these drugs to review the use of nsaids in the peri operative setting and their use in patients with osteoarthritis to further review the reported effects of nsaids on canine articular . Non steroidal anti inflammatory drugs nsaids form a large heterogeneous pharmacological family but they all have one thing in common the inhibition of one of the two cyclooxygenases these enzymes are involved in the cascade of arachidonic acid which leads to a decrease in the synthesis of prostaglandins. Full text full text is available as a scanned copy of the original print version get a printable copy pdf file of the complete article 139k or click on a page image below to browse page by page. Other mechanisms of action including inhibition of pa 2 may be responsible for its anti inflammatory effects carprofen has been used extensively in dogs since its introduction and adverse events have been comparable to those of other nsaids ie 2 events 1000 dogs treated approximately one fourth of the adverse reactions reported were gi signs including vomiting diarrhea and gi . Nonsteroidal anti inflammatory drugs nsaids are a drug class that reduce pain decrease fever prevent blood clots and in higher doses decrease inflammation side effects depend on the specific drug but largely include an increased risk of gastrointestinal ulcers and bleeds heart attack and kidney disease
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